Difference between Replication and Transcription

DNA replication is defined as the process of obtaining two virgin strands in which each strand contains part of the DNA double helix. This occurs in the S phase of the cell cycle. The enzymes involved in this process are DNA Polymerase and DNA Helicase.

Difference between Replication and Transcription

Transcription, on the other hand, is the process of transferring genetic information from DNA to RNA. This process occurs in the G1 and G2 phases of the cell. It is synthesized by RNA polymerase.

What Is Replication?

DNA replication is the process by which a double-stranded DNA molecule is split into two identical daughter strands.

Therefore during cell division, each daughter cell contains the same genetic information as the parent cell. The main enzyme responsible for DNA replication is DNA polymerase. Each strand adds a new nucleotide.

What Is Transcription?

Transcription is the conversion of DNA molecules into RNA. RNA polymerase uses one of the DNA strands as a template to make a complementary RNA molecule. The RNA molecule produced is known as a transcript

Difference between Replication and Transcription




S phase of the cell cycle G1 and G2 phase of the cell cycle


Requires RNA primer for replication to start Does not require a primer


DNA Polymerase, DNA Helicase RNA polymerase, Transcriptase

Genome copy

Entire genome is copied Only certain genes are copied


Found along the DNA strand Found only along 1 strand of DNA

Raw material

dATP, dTTP, dCTP and dGTP ATP, GTP, CTP, and UTP


Conserving genome for further generations Making copies of RNA of genes individually


Two daughter strands mRNA, rRNA, non-coding RNA and tRNA


Products do not degrade Products degrade

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